Villanova vs. Oklahoma prediction, odds, line: 2022 college basketball picks, Dec. 3 best bets by proven model

The Villanova Wildcats are looking to break out of their funk when they host the Oklahoma Sooners on Saturday in the 2022 Big East-Big 12 Battle. The Wildcats (2-5) are trying to find their footing after the retirement of coach Jay Wright, who led them to two national titles and last year’s Final Four. They are on a four-game losing streak, their most recent a 74-67 setback to Oregon at the Phil Knight Invitational last Sunday. Meanwhile, the Sooners (6-1) have won six in a row. They handed Ole Miss its first loss last Sunday, beating the Rebels 59-55 at the ESPN Events Invitational. OU will finally have a chance to avenge a 95-51 loss to the Wildcats in the 2016 Final Four as Villanova went on to its second championship. The only other meeting between the teams came earlier that season, a 78-55 Sooners victory.

Tip-off at the Wells Fargo Center is set for 12:30 p.m. ET. Caesars Sportsbook lists the Wildcats as 3-point favorites in the latest Oklahoma vs. Villanova odds, and the over/under for total points scored is 125.5. Before making any Villanova vs. Oklahoma picks, be sure you check out the college basketball predictions and betting advice from the SportsLine Projection Model.

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The model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,500 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns. 

Now, the model has broken down the Oklahoma vs. Villanova matchup from every angle and locked in its…