College Hoops

LSU vs. Illinois State odds, line, spread: 2022 Cayman Islands Classic picks, predictions from proven model

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The LSU Tigers will look to continue their dominance against their early-season opponents on Monday when they take on the Illinois State Redbirds in the first round of the 2022 Cayman Islands Classic. The Tigers (3-0) have won each of their games by nine points or more, including a 91-62 triumph over New Orleans on Thursday. The Illinois State Redbirds (2-2) have been in four tight games with all being decided by five points or less. The Redbirds are coming off a home-and-home series against Northwestern State, winning 69-67 on the road on Nov. 12 before losing at home 70-67 on Thursday.

The game from John Gray Gymnasium in George Town, Grand Cayman, tips off at 11 a.m. ET. LSU averages 75.3 points per game, while Illinois State averages 64.5. The Tigers are 14-point favorites in the latest Illinois State vs. LSU odds from Caesars Sportsbook, while the over/under for total points scored is set at 135. Before making any LSU vs. Illinois State picks, be sure to see the college basketball predictions and betting advice from SportsLine’s proven computer model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,200 for $100 players on its top-rated college basketball picks against the spread. 

Now, the model has set its sights on LSU vs. Illinois State and just locked in its picks and CBB predictions. You can visit SportsLine now to see the picks. Here are the college basketball odds and betting lines for Illinois State vs. LSU:

  • Illinois State vs. LSU spread: LSU -14
  • Illinois State vs. LSU over/under: 135 points
  • Illinois State vs. LSU money line: Illinois State +800, LSU -1400
  • ISU: The Redbirds are 7-2 against the spread in their last nine games against a team with a winning % above .600
  • LSU: The under is 5-0 in the Tigers’ last five games following a straight-up win of more than 20 points
  • Illinois State vs. LSU picks: See picks at SportsLine

Featured Game | LSU Tigers vs. Illinois State Redbirds

Why LSU can cover 

Senior forward KJ Williams, a transfer from

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